Potent Kv1.3 inhibitors from correolide-modification of the C18 position.

Jianming Bao,Shouwu Miao,Frank Kayser,Andrew J Kotliar,Robert K Baker,George A Doss,John P Felix,Randal M Bugianesi,Robert S Slaughter,Gregory J Kaczorowski,Maria L Garcia,Sookhee N Ha,Laurie Castonguay,Gloria C Koo,Kashmira Shah,Marty S Springer,Mary Jo Staruch,William H Parsons,Kathleen M Rupprecht

Bioorganic & Medicinal Chemistry Letters（2005）

引用 21|浏览46

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摘要

Correolide (1) was converted to a new series of tetracyclic Kv1.3 blockers 2. SAR for this class of compounds in two functional assays, Rb_Kv and human T cell proliferation, is presented herein.

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关键词

Potassium channel,Kv1.3,Correolide,Ion channel blocker,T cell,Immunosuppressant

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