Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism

    Nature Structural & Molecular Biology, Volume 12, Issue 9, 2005, Pages 756-762.

    Cited by: 104|Bibtex|Views1|Links
    WOS NATURE
    Keywords:
    proteinsdna recombinationdna replicationprotein foldingnucleic acidsMore(22+)

    Abstract:

    The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a simple model for the analogous heterohexameric eukaryotic complex. Here we investigate the organization and orientation of the MCM complex of the hyperthermophilic archaeon Sulfolobus solfataricus (Sso) on model DNA substrates. Sso MCM binds as a hexamer and...More

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