In vitro characterization of a human calcitonin receptor gene polymorphism

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, pp. 93-105, 2003.

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Keywords:
Calcitonin receptorPolymorphismsIn vitro characterization

Abstract:

Calcitonin is a 32 amino acid peptide hormone that inhibits bone resorption by stimulating calcitonin receptors (CTR) located on the surfaces of osteoclasts. A polymorphism at nucleotide 1340 of the human calcitonin receptor gene (CALCR) lies within the coding region and has the potential to change the amino acid at codon 447 from leucine...More

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