Nucleic acids with a six-membered carbohydrate mimic and RNA interference.
Blood Cells, Molecules, and Diseases(2007)
摘要
Cyclohexenyl nucleic acids and altritol nucleic acids were evaluated as RNA modifications in an siRNA experiment targeting the P-glycoprotein expression. Both modified oligonucleotides are well accepted as RNA mimics leading to an increase in potency and duration of action of the gene-silencing effect.
更多查看译文
关键词
SiRNA,Altritol nucleic acids,Cyclohexenyl nucleic acids,P-glycoprotein expression
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要