Solid-Phase Synthesis Of Di- And Tripeptidic Hydroxamic Acids As Inhibitors Of Procollagen C-Proteinase

Sharon M Dankwardt,Roland J Billedeau,Linda K Lawley,Sarah C Abbot,Robert L Martin,Christine S Chan,Harold E Van Wart,Keith A.M Walker

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2000）

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摘要

A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP). (C) 2000 Elsevier Science Ltd. All rights reserved.

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