Synthesis of new 3-thiosubstituted carbacephem antibiotics and their activity against penicillin resistant Streptococcus pneumoniae

Larry C. Blaszczak,Clark N. Eid,Jane Flokowitsch,G.Stuart Gregory,Stephen A. Hitchcock,George W. Huffman,Daniel R. Mayhugh,Michael J. Nesler,David A. Preston,Mohammad Zia-Ebrahimi

ChemInform（1997）

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摘要

The synthesis of a series of 3-thiosubstituted carbacephem derivatives is described. The compounds were assayed against penicillin susceptible, intermediate and resistant strains of Streptococcus pneumoniae. Several analogs displayed potent in vitro activity against these organisms. (C) 1997 Elsevier Science Ltd.

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关键词

carbacephem antibiotics,penicillin resistant streptococcus pneumoniae

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