Degeneration of skeletal muscle, peripheral nerves, and the central nervous system in transgenic mice overexpressing wild-type prion proteins

CELL, pp. 117-129, 1994.

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wild typecentral nervous systemtransgenic mice

Abstract:

Prion diseases of humans and animals are known to be caused by infection with prions containing PrP(Sc) or mutation of the prion protein (PrP) gene. During transgenetic studies, we discovered that uninoculated older mice harboring high copy numbers of wild-type (wt) PrP transgenes derived from Syrian hamsters (SHa), sheep (She), and PrP-B...More

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