Advancing Parallel Solution Phase Library Synthesis Through Efficient Purification, Quantitation, and Characterization Techniques

Historically, access to large numbers of quality compounds in a parallel solution phase library synthesis environment has been hindered by the inability to rapidly purify, quantitate, and characterize solution phase libraries in an efficient and cost effective manner. At Neurogen Corporation, we overcome these barriers by employing a collection of novel workstations in the High Speed Synthesis (HSS) group that are tightly integrated into our informatics architecture. This approach supports rapid and reliable instrument operation, rapid interpretation of results, and decision analysis for further downstream tasks and processing. Our movement of library samples and data from workstation to workstation facilitates synthesis throughput and the utilization of equipment, creating a cost-effective library production environment.