Improvement Of Pentobarbital-Induced Heart-Failure By Mci-154, A Novel And Potent Cardiotonic Agent, In The Dog Heart-Lung Preparation
Japanese journal of pharmacology(1988)
摘要
The efficacy of MCI-154, a new pyridazinone cardiotonic agent, in improving heart failure was assessed in dog heart-lung preparations in which cardiac function had been severely depressed by pentobarbital. MCI-154 in doses of 10-100 micrograms improved the cardiac function curve and restored it to the control level at 100 micrograms. At this dose, MCI-154 neither produced an increase in heart rate beyond the control value nor induced arrhythmias. The effects of MCI-154 were not affected by atenolol, a cardioselective beta 1-blocker. These results indicate that MCI-154 would be of potential use in the treatment of heart failure.
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关键词
potent cardiotonic agent,heart failure,pentobarbital-lnduced,heart-lung
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