Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors

Diane H. Boschelli,Daniel Wang,Yan Wang,Biqi Wu,Erick E. Honores,Ana Carolina Barrios Sosa,Inder Chaudhary,Jennifer Golas,Judy Lucas,Frank Boschelli

Bioorganic & Medicinal Chemistry Letters（2010）

引用 16|浏览25

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摘要

The 7-alkene-3-quinolinecarbonitrile 20, a potent inhibitor of Src enzymatic and cellular activity with IC50 values of 2.1 and 58nM, respectively, had comparable efficacy to bosutinib in a colon tumor xenograft study.

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关键词

3-Quinolinecarbonitrile,Src,Kinase

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