Therapeutic drug monitoring in antituberculosis chemotherapy: clinical perspectives.

Background: Therapeutic drug monitoring (TDM) represents an area where multidisciplinary service is rendered for optimization of clinical care, through enabling maximum drug therapeutic efficacy and minimum drug toxicity. This is a recently developed field for antituberculosis chemotherapy. The other goals of TDM principally include study and management of pharmacokinetic drug–drug and drug–disease interactions as well as the evaluation of new fixed-dose combinations (FDC) developed for treatment of tuberculosis. Conclusion: In the years to come, with the advancement in knowledge, technology and expertise, it is hoped that TDM, as a novel paradigm of care in tuberculosis, may gain expanding indications and reach a new horizon.