Are Urotensin II Effects on Vascular Tone in Heart Failure Mediated Via Soluble Epoxide Hydrolase?

all cause mortality 47% vs. 27% (p 1.2mg/dl; 23.3%vs. 10.6%, p< 0.01) and ischaemic aetiology (70%vs. 56%, p< 0.01). Adherence to medications was similar: ACEi/ARB (91%, p=NS), B blockers (67%, p=NS) and spironolactone (43%, p=NS). Independent predictors of mortality were: anaemia (HR 1.7 [1.2–2.4], p< 0.01), LV systolic function (HR 1.6 [1.3–2.1], p< 0.01), absence of B blocker therapy (HR 1.6 [1.1–2.3], p< 0.01), NYHA class (HR 1.4 [1.1–1.8], p< 0.01), and increasing age (HR 1.1 [1.0–1.1], p< 0.01) Conclusions: Despite good adherence to guideline based therapy in HFC, SHF mortality remains high. Anaemia is independently associated with mortality and screening for reversible causes and subsequent treatment if identified is advisable. doi:10.1016/j.hlc.2010.06.815