Multiple malformation syndrome following fluconazole use in pregnancy: Report of an additional patient

We report on a patient with malformations following long-term and high-dose maternal fluconazole use during pregnancy, The patient had exorbitism, a large pear-shaped nose, "dysplastic" ears, and radiohumeral synostosis. He is similar to three previously reported patients with in utero exposure to fluconazole and also shares some characteristics with the Antley-Bixler syndrome, The four fluconazole-exposed and malformed infants are compared with one another and with the Antley-Bixler syndrome, We conclude that fluconazole is a teratogen and results in a specific pattern of malformations following first trimester use. (C) 1997 Wiley-Liss, Inc.