ChemInform Abstract: Synthesis of Prodrug Candidates: Conjugates of Amino Acid with Nucleoside Boranophosphate.

[GRAPHIC] Preparation of antiviral and anticancer prodrug candidates, P-tyrosinyl(P-O)-5'-P-nucleosidyl boranophosphates, is described. One-pot synthesis via a phosphoramidite method resulted in the title compounds with good yields. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by H-1 and P-31 NMR spectroscopy and MS analysis.