Identification of Formulation and Manufacturing Variables That Influence In Vitro Dissolution and In Vivo Bioavailability of Propranolol Hydrochloride Tablets

Natalie D. Eddington,Muhammad Ashraf,Larry L. Augsburger,James L. Leslie,Michael J. Fossler,Lawrence J. Lesko,Vinod P. Shah,Gurvinder Singh Rekhi

Pharmaceutical Development and Technology（2008）

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摘要

The purpose of this study was to evaluate the effect of formulation and processing changes on the dissolution and bioavailability of propranolol hydrochloride tablets. Directly compressed blends of...

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