CP5484, a novel quaternary carbapenem with potent anti-MRSA activity and reduced toxicity.

Takahisa Maruyama,Yasuo Yamamoto,Yuko Kano,Mizuyo Kurazono,Eiji Matsuhisa,Hiromi Takata,Toshihiko Takata,Kunio Atsumi,Katsuyoshi Iwamatsu,Eiki Shitara

Bioorganic & Medicinal Chemistry（2007）

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摘要

A new series of 1β-methyl carbapenems possessing a 6,7-disubstituted imidazo[5,1-b]thiazol-2-yl group was prepared. Among them CP5484 showed potent anti-MRSA activity with reduced acute toxicity in mice. Further evaluaton of CP5484 is also reported.

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关键词

Carpabapenem,MRSA,CP5484,Toxicity,Anti-MRSA activity

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