ChemInform Abstract: The Design of (-)-(S)-2-Nitrooxyethyl 1,4-Dihydro-2,6-dimethyl-3-nitro-4- (2-trifluoromethylphenyl)pyridine-5-carboxylate: A Cardioselective Positive Inotropic Derivative of Bay K 8644.

The title compound, (-)-(S)-9, is a novel cardioselective calcium channel modulator that exhibits a calcium channel agonist effect on heart, a weak calcium channel antagonist effect on smooth muscle, and releases nitric oxide in vitro. (-)-(S)-9 is a useful lead-compound for the design of positive inotropic agents to treat congestive heart failure, and to study the structure-function relationship of calcium channel modulation.