Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists

Kenneth M. Meyers,José Méndez-Andino,Anny-Odile Colson,X. Eric Hu,John A. Wos,Maria C. Mitchell,Karen Hodge,Jeremy Howard,Jennifer L. Paris,Martin E. Dowty,Cindy M. Obringer,Ofer Reizes

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

The synthesis and biological testing of novel classes of potent melanin-concentrating hormone (MCH-R1) antagonists based on pyrazolopiperazinone and pyrrolopiperazinone scaffolds are described.

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关键词

Melanin-concentrating hormone,MCH-R1 antagonists,5HT-2C receptor,Obesity,Pyrazolopiperazinone,Pyrrolopiperazinone

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