Dynamic contrast-enhanced MRI in diagnosis of central gland prostate cancer and benign prostatic hyperplasia

Objective To explore the value of 3.0Tliver acquisition with volume acceleration(LAVA) dynamic contrastenhanced MRI(DCE-MRI) in the diagnosis of central gland prostate cancer(CGPCa) and benign prostatic hyperplasia(BPH).Methods MRI and DCE-MRI data of 34patients with CGPCa(CGPCa group) and 70patients with BPH(BPH group) proved by pathology were analyzed retrospectively.By analyzing the characteristics of T2WI and DCE-MRI,the styles of the signal intensity-time curve(SI-T) were defined as rapidly ascending followed with descending curve,rapidly ascending followed with plateau curve,slowly ascending followed with plateau curve and persistently and slowly ascending curve.Time to minimum(T max),whole enhancement degree(SI max) and maximum slope(R max) of the first three curve were calculated,and the differences of SI-T curve type and T max,SI max and R max between the two groups were compared.Results The most common styles of SI-T curve in CGPCa group were rapidly ascending followed with descending curve and rapidly ascending followed with plateau curve.The stromal BPH(sBPH) subgroup was similar as CGPCa group.The most common style of SI-T curve in glandular BPH(gBPH) subgroup was persistently and slowly ascending curve.The 4 kinds of curves were visible in the mixture BPH(mBPH) subgroup,but the persistently and slowly ascending curve was most common.The differences of SI-T curve styles among CGPCa group,sBPH subgroup,mBPH subgroup and gBPH subgroup were statistically significant(P0.01),but that between CGPCa group and sBPH subgroup was not significant(P0.05),whereas those between CGPCa group and gBPH subgroup,mBPH subgroup were statistically significant,respectively(both P0.01).The differences of T max,SI max and R max among CGPCa group,sBPH subgroup and mBPH subgroup were also significant(all P0.05),but the value in CGPCa group and sBPH subgroup was overlapped.Conclusion The style of SI-T curve of 3.0TLAVA DCE-MRI is helpful to diagnose CGPCa,gBPH and mBPH.T max,SI max and R max play centain role in the differential diagnosis of CGPCa,sBPH and mBPH.