Understanding DP receptor antagonism using a CoMSIA approach.

Lan Mu,Joacy Aguiar,Ali Ardati,Bin Cao,Charles J Gardner,Tim Gillespy,Keith Harris,Sungtaek Lim,Robert Marcus,Isabelle Morize,Ashfaq Parkar,David Stefany,Yi Li,Roy J Vaz,Dragan A Cirovic

Bioorganic & Medicinal Chemistry Letters（2011）

引用 2|浏览34

暂无评分

摘要

CoMSIA model of 2,6-substituted-4-monosubstituted aminopyrimidine antagonists of prostaglandin D2 receptor (DP1) is reported. The utility of this QSAR model in chemical lead optimization is discussed.

查看译文

关键词

CoMSIA,QSAR,DP,DP1,Prostaglandin,PGD2,GPCR

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要