Melanocortin subtype 4 receptor agonists: Structure–activity relationships about the 4-alkyl piperidine core

Iyassu K. Sebhat,Yingjie Lai,Khaled Barakat,Zhixiong Ye,Rui Tang,Rubana N. Kalyani,Aurawan Vongs,Tanya MacNeil,David H. Weinberg,M. Angeles Cabello,Marta Maroto,Ana Teran,Tung M. Fong,Lex H.T. Van der Ploeg,Arthur A. Patchett,Ravi P. Nargund

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

SAR about the piperidine core in a series of MC4R agonists is described. A number of alkyl substituents that furnish compounds with good affinity and functional potency are reported.

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Obesity,Erectile dysfunction,Privileged structure,G-protein-coupled receptor,Apetite,Metabolic disorder,Peptidomimetic

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