Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy

    Critical care (London, England), Volume 15, Issue 3, 2011, Pages R137-R137.

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    Keywords:
    minimal inhibitory concentrationhigh performance liquid chromatographyspectrumprospective study

    Abstract:

    Sepsis is responsible for important alterations in the pharmacokinetics of antibiotics. Continuous renal replacement therapy (CRRT), which is commonly used in septic patients, may further contribute to pharmacokinetic changes. Current recommendations for antibiotic doses during CRRT combine data obtained from heterogeneous patient populat...More

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