In Vitro Susceptibility And Molecular Analysis Of Gentamicin-Resistant Enterococci
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE(1998)
摘要
Enterococci with gentamicin MICs of 256 to 1,024 mu g/mL were evaluated for susceptibility to ampicillin pins gentamicin synergism. Sixteen of eighteen enterococcal isolates were not susceptible to synergistic killing by ampicillin plus gentamicin; II possessed aac(6')-aph(2 "), and 4 possessed aph(2 ")-Ic. A gentamicin MIC of 512 ou 1,024 mu g/mL predicted lack of ampicillin/gentamicin synergism, but a gentamicin MIC of 256 mu g/mL did not. For six enterococcal strains possessing the gentamicin-resistance gene aph(2 ")-Ic, ampicillin pills dibekacin, ampicillin plus netilmicin, and ampicillin pills amikacin produced synergistic killing in five, three, and two strains, respectively. (C) 1998 Elsevier Science Inc.
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