Error Detection for Genetic Data Using Likelihood Methods
American Journal of Human Genetics, Volume 58, Issue 1, 1996.
As genetic maps become denser, the effect of laboratory typing errors becomesmore serious. We review a general method for detecting errors in pedigreegenotyping data which is a variant of the likelihood ratio test statistic. Itpinpoints individuals and loci with relatively unlikely genotypes. Power andsignificance studies using Monte Car...More
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