Error Detection for Genetic Data Using Likelihood Methods

AMERICAN JOURNAL OF HUMAN GENETICS, pp. 225-234, 1996.

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Abstract:

As genetic maps become denser, the effect of laboratory typing errors becomes more serious. We review a general method for detecting errors in pedigree genotyping data that is a variant of the likelihood-ratio test statistic. It pinpoints individuals and loci with relatively unlikely genotypes. Power and significance studies using Monte C...More

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