Error Detection for Genetic Data Using Likelihood Methods

American Journal of Human Genetics, Volume 58, Issue 1, 1996.

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Abstract:

As genetic maps become denser, the effect of laboratory typing errors becomesmore serious. We review a general method for detecting errors in pedigreegenotyping data which is a variant of the likelihood ratio test statistic. Itpinpoints individuals and loci with relatively unlikely genotypes. Power andsignificance studies using Monte Car...More

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