Quercetin increases the bioavailability of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats

Maaike E. Schutte,Gerrit M. Alink,Andreas P. Freidig,Bert Spenkelink,Judith C.H. Vaessen,Johannes J.M. van de Sandt,John P. Groten,Ivonne M.C.M. Rietjens

Food and Chemical Toxicology（2008）

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摘要

This study investigates whether the previous observation that quercetin increases the transport of PhIP through Caco-2 monolayers in vitro could be confirmed in an in vivo rat model.

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关键词

ABC,BCRP,CYP,MDCK,MRP,P-gp,PhIP,SD,SEM

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