Chapter 2 Cutting the Gordian Knot-Development and Biological Relevance of Hepatitis C Virus Cell Culture Systems

    Advances in Virus Research, pp. 51-133, 2008.

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    Keywords:
    life cyclecell culturecell linegenetics

    Abstract:

    Worldwide ∼180 million people are chronically infected with hepatitis C virus (HCV). HCV isolates exhibit extensive genetic heterogeneity and have been grouped in six genotypes and various subtypes. Additionally, several naturally occurring intergenotypic recombinants have been described. Research on the viral life cycle, efficient therap...More

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