Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations

Paul N. Newton,Steven Ward,Brian J. Angus,Wirongrong Chierakul,Arjen Dondorp,Ronnatrai Ruangveerayuth,Kamolrat Silamut,Pramote Teerapong,Yupin Suputtamongkol,Sornchai Looareesuwan,Nicholas J. White

Transactions of the Royal Society of Tropical Medicine and Hygiene（2006）

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摘要

A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.

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关键词

Malaria,Plasmodium falciparum,Quinine,Pharmacokinetics,Treatment failure,Thailand

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