In vitro metabolism of a new 4-hydroxycoumarin anticoagulant. Structure of an unusual metabolite.
JOURNAL OF MEDICINAL CHEMISTRY（1977）
摘要
The metabolism of clocoumarol, 3-[1-[P-(2-chlorethyl)phenyl]butyl]-4-hydroxycoumarin, by rat liver microsomes was investigated. The chemical structure of the main metabolite is 6-[1-hydroxy-2-oxo-3-[p-(2-chloro
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