Differences in lopinavir plasma concentrations comparing Kaletra film coated tablets and soft gelatine capsules that result in various lipid abnormalities.

Judit Morello,Vincent Soriano,Francisco Blanco,Antonio J Rubio,Inmaculada Jiménez-Nácher,Sonia Rodríguez-Nóvoa

Drug metabolism letters（2009）

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摘要

Changes in lipids and lopinavir plasma concentrations were examined in 40 HIV-patients exposed to lopinavir/ritonavir 400/100 mg BID, formulated as tablets and as capsules. Triglycerides and total/HDL-cholesterol ratio were significantly lower with tablets than with capsules. Lopinavir concentrations were higher with tablets than with capsules.

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