Isolation, structure elucidation, and mutagenicity of four alternariol derivatives produced by the mangrove endophytic fungus No. 2240
Chemistry of Natural Compounds(2008)
摘要
A new alternariol derivative, 2240B ( 1 ), together with alternariol ( 2 ), alternariol 4,10-dimethyl ether ( 3 ), and alternariol 4-methyl ether ( 4 ), was isolated from the ethyl acetate extract of the liquid medium GYT of No. 2240, the mangrove endophytic fungus from the South China Sea Coast. The structure of compound 1 was unambiguously elucidated as alternariol 4-methyl-10-acethyl ester by spectra including one/two-dimensional NMR, HREIMS, IR, and UV. The structures of compounds 2–4 were also established by spectroscopic analyses and comparison with related literature data. The anticancer tests showed that compounds 2 and 4 had strong activities against KB and KBv200 cells with IC 50 values of 3.17, 3.12, and 4.82, 4.94 µg/mL, while compounds 1 and 3 exhibited weak activities against the two kinds of tumor lines with IC 50 values of more than 50 µg/mL.
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关键词
alternariol derivatives,mangrove endophytic fungus,alternariol 4-methyl-10-acethyl ester,mutagenicity,KB tumor lines,KBv200
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