Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseases

The objective of the study was to look at the in vivo expression of serglycin in cells taken from patients with an inflammatory disease. The mRNA expression of the small proteoglycan serglycin was investigated in macrophages;monocytes and T-cells derived from the synovial fluid and blood or six patients with various rheumatic diseases and from the blood of two control subjects. Our results demonstrate higher levels of expression in CD14+ cells taken from patients with chronic inflammatory diseases than in control subjects. This suggests that serglycin may play a role during the inflammatory process.