Sulpirid versus haloperidol i behandling af skizofreni: En kort, prsæliminær rapport

Twenty-eight patients with schizophrenia were included in this double-blind crossover study and were randomly assigned to treatment with either sulpiride or haloperidol. The study has demonstrated an antipsychotic effect of sulpiride, not significantly different from that of haloperidol. The dose level used for treatment varied from 800 to 3200 mg sulpiride. Even high doses of sulpiride appeared to induce very few extrapyramidal side effects. The observation of good antipsychotic effect of sulpiride, a neuroleptic that selectively binds to a subpopulation of D-2 dopamine receptors, may call for consideration of the relationship between the dopamine receptors and the antipsychotic mechanisms of action of neuroleptic drugs.