No association between a transcription factor Activating Protein 2β (AP-2β) gene variant and schizophrenia

Genetic components are involved in the aetiology of schizophrenia. Activating Protein 2 (AP-2) transcription factors are essential for neural gene expression and neural development. Transcription factor AP-2β has also been connected with monoaminergic genes and monoamine levels in various brain regions. Thus, the AP-2β gene is a suitable candidate taking both the neurodevelopmental and dopamine hypotheses of schizophrenia into account. We investigated 135 schizophrenic patients and 382 control subjects with regard to an intronic AP-2β variant without evidence of any association. We conclude that the investigated AP-2β variant is not of major importance to schizophrenia in the investigated Swedish population.