Efficient C2 Functionalisation Of 2h-2-Imidazolines

Robin S. Bon,Nanda E. Sprenkels,Manoe M. Koningstein,Rob F. Schmitz,Frans J. J. de Kanter,Alexander Dömling,Marinus B. Groen,Romano V. A. Orru

ORGANIC & BIOMOLECULAR CHEMISTRY（2008）

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摘要

Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).

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