An Efficient Laboratory Synthesis Of Alpha-Deuteriated Profens

Gregory S. Coumbarides,Marco Dingjan,Jason Eames,Anthony Flinn,Julian Northen

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS（2006）

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摘要

An efficient and practical laboratory synthesis of a series of 2-deuterio-2-arylpropionic acids (alpha-deuterioprofens) is described. The levels of deuterium incorporation are high and the products are synthetically useful. Copyright (c) 2006 John Wiley & Sons, Ltd.

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carboxylic acids, deuterium, 2-phenyl-propionic acid and profens

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