4-Substituted anilides as selective melatonin MT2 receptor agonists

James R. Epperson,Jeffrey A. Deskus,Anthony J. Gentile,Lawrence G. Iben,Elaine Ryan,Nathan S. Sarbin

Bioorganic & Medicinal Chemistry Letters（2004）

引用 16|浏览14

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摘要

A series of 4-substituted anilides with human melatonergic affinity is reported. Butyramides 26, 39, 42, 52, 57, and 58 all demonstrated subnanomolar MT2 binding affinity and MT2 selectivity of at least 70-fold over the MT1 receptor. Compound 26 demonstrated full agonism at the MT2 receptor.

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melatonin,receptor

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