Response to Dr Stephen Cooper's âOn the use of metaphor to understand, explain, or rationalize redundant genes in yeastâ
FEMS YEAST RESEARCH(2008)
摘要
Earlier use of a metaphor in explaining genetic redundancy in a news article has triggered a commentary and a competing metaphor by Dr Stephen Cooper, who went on to conclude that genetic redundancies are relatively unimportant for microorganisms. We argue here that the new metaphor is flawed and that genetic redundancies are integral to buffering all organisms against environmental and genetic damage.
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关键词
synthetic lethality,Saccharomyces cerevisiae,genetic interactions,DNA repair,DNA replication
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