Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode

Richard M. Angell,Paul Bamborough,Anne Cleasby,Stuart G. Cockerill,Katherine L. Jones,Christopher J. Mooney,Donald O. Somers,Ann L. Walker

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

The biphenyl amides (BPAs) are a novel series of p38α MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

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关键词

p38 kinase,p38 alpha,p38,CSBP,MAP kinase,Inhibitors,Biphenyl amide,BPA,Biphenyl amides,BPAs,Protein kinase X-ray structure,Binding mode,Pharmacophore search,Focused screen,Virtual screening,Structure-based drug design,kinase selectivity

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