Origin Of Cd57(+) T-Cells Which Increase At Tumor Sites In Patients With Colorectal-Cancer

Human T cells carrying natural killer (NK) markers, CD57 or CD56 antigens, appear to be distinguishable from other T cell subsets in terms of their granular lymphocyte morphology and their numerical increase in patients with AIDS and in recipients of bone marrow transplantation. At the begining of this study, we observed that CD57(+) T cells as well as CD56(+) T cells were abundant at tumour sites in many patients with colorectal cancer. Since all these findings for CD57(+) T cells are quite similar to those of extrathymic T cells seen in mice, we investigated how CD57(+) T cells are distributed to various immune organs in humans. They were found to be present mainly in the bone marrow and liver, but to be completely absent in the thymus. Similar to the case of extrathymic T cells in mice, they were observed to consist of double-negative CD4(-)8(-) subsets as well as single-positive subsets (preponderance of CD8(+) cells), and to contain a considerable proportion of gamma delta T cells. These features are striking when compared with those of CD57(-) T cells, which are characterized by an abundance of CD4(+) subsets and alpha beta T cells. Not only at tumour sites but also in the peripheral blood, some patients with colorectal cancer displayed elevated levels of CD57(+) cells. These results suggest that CD57(+) T cells may be of extrathymic origin, possibly originating in the bone marrow and liver, and may be associated with tumour immunity, similar to another extrathymic population of CD56(+) T cells in humans.