A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer

Lambertus A Kiemeney,Patrick Sulem,Soren Besenbacher,Sita H Vermeulen,Asgeir Sigurdsson,Gudmar Thorleifsson,Daniel F Gudbjartsson,Simon N Stacey,Julius Gudmundsson,Carlo Zanon,Jelena Kostic,Gisli Masson,Hjordis Bjarnason,Stefan T Palsson,Oskar B Skarphedinsson,Sigurjon A Gudjonsson,J Alfred Witjes,Anne J Grotenhuis,Gerald W Verhaegh,D Timothy Bishop,Sei Chung Sak,Ananya Choudhury,Faye Elliott, Jennifer H Barrett,Carolyn D Hurst,Petra J de Verdier,Charlotta Ryk,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Paolo Vineis,Silvia Polidoro,Simonetta Guarrera,Carlotta Sacerdote,Marcello Campagna,Donatella Placidi,Cecilia Arici,Maurice P Zeegers,Eliane Kellen,Berta Saez Gutierrez,José I Sanz-Velez, Manuel Sanchez-Zalabardo,Gabriel Valdivia,Maria D Garcia-Prats,Jan G Hengstler,Meinolf Blaszkewicz,Holger Dietrich,Roel A Ophoff,Leonard H van den Berg,Kristin Alexiusdottir,Kristleifur Kristjansson,Gudmundur Geirsson,Sigfus Nikulasson,Vigdis Petursdottir,Augustine Kong,Thorgeir Thorgeirsson, N Aydin Mungan,Annika Lindblom,Michael A van Es,Stefano Porru,Frank Buntinx,Klaus Golka,José I Mayordomo,Rajiv Kumar,Giuseppe Matullo,Gunnar Steineck,Anne E Kiltie,Katja K H Aben,Eirikur Jonsson,Unnur Thorsteinsdottir,Margaret A Knowles,Thorunn Rafnar,Kari Stefansson

Nature Genetics（2010）

引用 165|浏览57

暂无评分

摘要

Thorunn Rafnar and colleagues identify a variant on 4p16.3 near FGFR3 associated with increased risk of urinary bladder cancer. They find that the risk allele is more frequent among individuals with tumors that carry an activating somatic mutation in FGFR3 , suggesting a link between germline variation, somatic mutation status and cancer risk.

查看译文

关键词

bladder,sequence variant,cancer

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要