Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop

    Cellular Signalling, pp. 212-219, 2009.

    Cited by: 62|Bibtex|Views2|Links
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    Abstract:

    The epidermal growth factor receptor (EGFR) and its ligand amphiregulin (AR) have been shown to be co-over expressed in breast cancer. We have previously shown that an AR/EGFR autocrine loop is required for SUM149 human breast cancer cell proliferation, motility and invasion. We also demonstrated that AR can induce these altered phenotype...More

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