Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein

The Journal of neuroscience : the official journal of the Society for Neuroscience, Volume 17, Issue 20, 1997, Pages 7655-7661.

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cerebral blood flowstroketransgenic micemiddle cerebral arteryalzheimer's diseaseMore(2+)

Abstract:

We studied the role of the amyloid precursor protein (APP) in ischemic brain damage using transgenic mice overexpressing APP. The middle cerebral artery (MCA) was occluded in FVB/N mice expressing APP695.SWE (Swedish mutation) and in nontransgenic littermates. Infarct volume (cubic millimeters) was assessed 24 hr later in thionin-stained ...More

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