Caged mitochondrial uncouplers that are released in response to hydrogen peroxide.
Tetrahedron(2010)
摘要
Caged versions of the most common mitochondrial uncouplers (proton translocators) have been prepared that sense the reactive oxygen species (ROS) hydrogen peroxide to release the uncouplers 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) from caged states with second order rate constants of 10 (±0.8)M−1s−1 and 64.8 (±0.6)M−1s−1, respectively. The trigger mechanism involves conversion of an arylboronate into a phenol followed by fragmentation. Hydrogen peroxide-activated uncouplers may be useful for studying the biological process of ageing.
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关键词
Mitochondria,Caged,Uncoupler,Boronate,Hydrogen peroxide,Ageing,Oxidative stress,ROS
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