Lack of autoregulatory blood flow escape in the skin after infusion of therapeutic levels of noradrenaline through a microdialysis system in healthy volunteers

In burn-injured patients we have previously shown that skin has a decreased autoregulatory blood flow adjustment. Lack of such a function in skin would make uncontrolled use of vasoconstrictors detrimental to this organ. If ischemia-like conditions are produced in the skin, use could enhance the inflammatory response and increase the risk of organ dysfunction. We exposed local areas of the skin in healthy volunteers to therapeutic levels of noradrenaline (NA) by infusion through microdialysis (MD) intradermally, to investigate whether autoregulatory escape is present in the skin during strong α1-adrenergic stimulation.