The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors.

Mui Cheung,Philip A Harris,Jennifer G Badiang,Gregory E Peckham,Stanley D Chamberlain,Michael J Alberti,David K Jung,Stephanie S Harris,Neal H Bramson,Andrea H Epperly,Stephen A Stimpson,Michael R Peel

Bioorganic & Medicinal Chemistry Letters（2008）

引用 47|浏览45

暂无评分

摘要

A series of pyrazolo[1,5-a]pyridine derivatives was designed and synthesized as novel potent p38 kinase inhibitors. Our approaches towards improving in vitro metabolism and in vivo pharmacokinetic properties of the series are described.

查看译文

关键词

CSBP,MAP kinase,PBMNC,SAR

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要