Synthesis and evaluation of chiral bicyclic proline FKBP12 ligands

David C. Limburg,Bert E. Thomas,Jia-He Li,Mike Fuller,Dawn Spicer,Yi Chen,Hongzhi Guo,Joseph P. Steiner,Gregory S. Hamilton,Yong-Qian Wu

Bioorganic & Medicinal Chemistry Letters（2004）

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摘要

As part of our ongoing program to explore novel structural classes of FKBP12 ligands, we herein wish to report a new class of FKBP12 ligands containing chiral bicyclic proline analogues. Details of the synthetic routes, together with preliminary biological activity, will be presented.

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