Modulation of endothelial cell growth arrest and apoptosis by vascular endothelial growth inhibitor

J Yu (季宇彬)

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Circulation research, Volume 89, Issue 12, 2001, Pages 1161-1167.

Cited by: 128|Views4

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Keywords:

angiogenesis n apoptosis n cell cycle n cytokine n endothelialcell cyclecyclin dependent kinaseendothelial cellannexin vMore(3+)

Abstract:

Vascular endothelial growth inhibitor (VEGI), a new member of the tumor necrosis factor family, is an endothelial cell-specific gene and a potent inhibitor of endothelial cell proliferation, angiogenesis, and tumor growth. We report here that VEGI mediates the following two activities in endothelial cells: early G(1) arrest in G(0)/G(1) c...More

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