Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach—Part 1

Michael P. Dwyer,Kamil Paruch,Marc Labroli,Carmen Alvarez,Kerry M. Keertikar,Cory Poker,Randall Rossman,Thierry O. Fischmann,Jose S. Duca,Vincent Madison,David Parry,Nicole Davis,Wolfgang Seghezzi,Derek Wiswell,Timothy J. Guzi

Bioorganic & Medicinal Chemistry Letters（2011）

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摘要

The synthesis and SAR development of a pyrazolo[1,5-a]pyrimidine-based structural series is described which led to the identification of potent, selective CHK1 inhibitors such as 17r.

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关键词

Kinase,CHK1,Pyrazolo[1,5-a]pyrimidine,Template

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