Free Interleukin (IL)-18 Levels, and the Impact of IL18 and IL18BP Genetic Variation, in CHD Patients and Healthy Men
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY(2010)
摘要
Objective - To investigate free interleukin-18 (fIL-18) levels, and variation within the IL-18 system genes, in heart surgery patients, and healthy men. Methods and Results - fIL-18 was calculated from IL-18 and IL-18 binding protein (BP) levels, in 421 healthy men and 196 post -coronary artery bypass graft (CABG) patients. After surgery, fIL-18 peaked at 6 hours (from 117 to 331 pg/mL) but fell to below presurgery levels at 24 hours (99 pg/mL), because of changes in total IL-18 and IL-18BP. fIL-18 24 hours postsurgery was significantly higher in those who suffered a major complication after surgery (125 versus 80 pg/mL, P < 0.01). Baseline total IL-18 was also higher in healthy men who went on to suffer an MI over 17 years of prospective study (276 versus 240 pg/mL, P = 0.01). Tagging SNPs for IL18 (n = 5) and IL18BP (n = 3) were determined, in both studies the IL18 HapIII haplotype (frequency 30%) was associated with 36% lower baseline fIL-18 levels before surgery (P < 0.01), and 7% lower in healthy men (P = 0.04). The frequency of HapIII was lower in CABG patients than in healthy men (20.7 versus 29.8%, P < 0.01). Conclusions - IL-18 levels, which are determined in part by variation in IL18, play a role in CHD development and postsurgery outcome.
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关键词
IL-18,IL-18BP,polymorphism,surgery,atherosclerosis
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