Conjugation of Oligonucleotides with Steroid Structures and Their Interaction with the Low-Density Lipoprotein

Erik Rump,Remco de Vrueh,Erik Biessen,Theo van Berkel,Martin Bijsterbosch

NUCLEOSIDES & NUCLEOTIDES（1997）

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摘要

To induce association with low-density lipoprotein (LDL), antisense oligonucleotides were derivatized at their 3' terminus with several steroid structures. It was found that only highly lipidic steroids can complex the oligonucleotide with LDL.

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